Protective Effect of Antenatal Antioxidant on Nicotine-Induced Heart Ischemia-Sensitive Phenotype in Rat Offspring.

@article{Xiao2016ProtectiveEO,
  title={Protective Effect of Antenatal Antioxidant on Nicotine-Induced Heart Ischemia-Sensitive Phenotype in Rat Offspring.},
  author={Daliao Xiao and Lei Wang and Xiaohui Huang and Yong Li and Chiranjib Dasgupta and Lubo Zhang},
  journal={PloS one},
  year={2016},
  volume={11 2},
  pages={e0150557}
}
Fetal nicotine exposure increased risk of developing cardiovascular disease later in life. The present study tested the hypothesis that perinatal nicotine-induced programming of heart ischemia-sensitive phenotype is mediated by enhanced reactive oxygen species (ROS) in offspring. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps from day 4 of gestation to day 10 after birth, in the absence or presence of a ROS inhibitor, N-acetyl-cysteine (NAC) in drinking water… CONTINUE READING
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