Protection of vascular endothelial cells from high glucose-induced cytotoxicity by emodin.

  title={Protection of vascular endothelial cells from high glucose-induced cytotoxicity by emodin.},
  author={Y. Gao and J. Zhang and G. Li and H. Xu and Yun Yi and Qin Wu and Miaomiao Song and Y. Bee and L. Huang and Mengxia Tan and S. Liang},
  journal={Biochemical pharmacology},
  volume={94 1},
  • Y. Gao, J. Zhang, +9 authors G. Li
  • Published 2015
  • Biology, Medicine
  • Biochemical pharmacology
  • Induction of endothelial cytotoxicity by hyperglycemia in diabetes has been widely accepted. Emodin is a natural anthraquinone in rhubarb used for treatment of diabetes, but its mechanism of action is not fully understood. This study aimed to examine the potential beneficial effects of emodin on endothelial cytotoxicity caused by high glucose milieu. Culture of human umbilical vein endothelial cells (HUVECs) with high concentrations of glucose resulted in damage to the cells, leading to… CONTINUE READING
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