Protection of tree shrews by pVAX-PS DNA vaccine against HBV infection.

@article{Zhou2003ProtectionOT,
  title={Protection of tree shrews by pVAX-PS DNA vaccine against HBV infection.},
  author={F Zhou and Zhen-lin Hu and Jian-xin Dai and Rui-Wen Chen and Ke Zhang Shi and Yi G. Lin and Shu-Han Sun},
  journal={DNA and cell biology},
  year={2003},
  volume={22 7},
  pages={475-8}
}
The immunological protection of pVAX-PS, a DNA vaccine, was assessed in the tree shrews model. pVAX-PS was constructed by inserting the gene encoding the middle (pre-S2 plus S) envelope protein of HBV into a plasmid vector pVAX1. Tree shrews (Tupaia belangeri chinenesis) were experimentally infected with human HBV by inoculation with human serum positive for HBV markers. DNA vaccination-induced seroconversion and antibody to HBV surface antigen (anti-HBs) were analyzed by ELISA, and protective… CONTINUE READING