Protection of the vascular endothelium in experimental situations

  title={Protection of the vascular endothelium in experimental situations},
  author={Ru{\vz}ena Sotn{\'i}kov{\'a} and Jana Nedel{\vc}evov{\'a} and Jana Navarov{\'a} and Viera Nos{\'a}ĺov{\'a} and Katar{\'i}na Dr{\'a}bikov{\'a} and Katalin Sz{\"o}cs and Peter Krenek and Zuzana Kyseĺov{\'a} and {\vS}tefan Bezek and Vladim{\'i}r Knezl and J{\'a}n Dř{\'i}mal and Zuzana Broskov{\'a} and Viera Kristov{\'a} and L'udmila Okruhlicov{\'a} and Iveta Bernatova and Viktor Bauer},
  booktitle={Interdisciplinary toxicology},
One of the factors proposed as mediators of vascular dysfunction observed in diabetes is the increased generation of reactive oxygen species (ROS). This provides support for the use of antioxidants as early and appropriate pharmacological intervention in the development of late diabetic complications. In streptozotocin (STZ)-induced diabetes in rats we observed endothelial dysfuction manifested by reduced endothelium-dependent response to acetylcholine of the superior mesenteric artery (SMA… CONTINUE READING