Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human papillomavirus type 16 minor capsid antigen L2.

@article{Gambhira2007ProtectionOR,
  title={Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human papillomavirus type 16 minor capsid antigen L2.},
  author={Ratish Gambhira and Subhashini Jagu and Balasubramanyam Karanam and Patti Gravitt and Timothy D. Culp and Neil D. Christensen and Richard B S Roden},
  journal={Journal of virology},
  year={2007},
  volume={81 21},
  pages={
          11585-92
        }
}
Current L1 virus-like particle (VLP) vaccines provide type-restricted protection against a small subset of the human papillomavirus (HPV) genotypes associated with cervical cancer, necessitating continued cytologic screening of vaccinees. Cervical cancer is most problematic in countries that lack the resources for screening or highly multivalent HPV VLP vaccines, suggesting the need for a low-cost, broadly protective vaccinogen. Here, N-terminal L2 polypeptides comprising residues 1 to 88 or 11… CONTINUE READING
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