Protection of piglets against Edema disease by maternal immunization with Stx2e toxoid.

@article{Oanh2012ProtectionOP,
  title={Protection of piglets against Edema disease by maternal immunization with Stx2e toxoid.},
  author={Thi Kim Nguyen Oanh and Viet Khong Nguyen and Henri de Greve and Bruno Maria Goddeeris},
  journal={Infection and immunity},
  year={2012},
  volume={80 1},
  pages={469-73}
}
Edema disease (ED) in piglets is caused by Shiga toxin Stx2e-producing Escherichia coli. We show that a genetically disarmed Stx2e toxoid is a safe antigen that generates antiserum protecting piglets against the Stx2e toxin. Immunization of suckling piglets with the Stx2e toxoid was safe, had no adverse effects on growth of the piglets, and resulted in effective prevention of edema disease clinical symptoms after challenge with the Stx2e toxin. Our data showed that maternal immunity against the… CONTINUE READING