Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis

@article{Zhao2008ProtectionOP,
  title={Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis},
  author={Wen Zhao and Guo-Chang Fan and Zhi-guo Zhang and Arun Bandyopadhyay and Xiaoyang Zhou and Evangelia G Kranias},
  journal={Basic Research in Cardiology},
  year={2008},
  volume={104},
  pages={377-389}
}
Peroxiredoxin II, a cytosolic isoform of the antioxidant enzyme family, has been implicated in cancer-associated cell death and apoptosis, but its functional role in the heart remains to be elucidated. Interestingly, the expression levels of peroxiredoxin II were decreased in mouse hearts upon ischemia-reperfusion, while they were elevated in two genetically modified hyperdynamic hearts with phospholamban ablation or protein phosphatase 1 inhibitor 1 overexpression. To delineate the functional… CONTINUE READING

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