Protection of neonatal rat brain from hypoxic-ischemic injury by LY379268, a Group II metabotropic glutamate receptor agonist.

@article{Cai1999ProtectionON,
  title={Protection of neonatal rat brain from hypoxic-ischemic injury by LY379268, a Group II metabotropic glutamate receptor agonist.},
  author={Zhengwei Cai and Fei Xiao and Jonathan D. Fratkin and Philip G. Rhodes},
  journal={Neuroreport},
  year={1999},
  volume={10 18},
  pages={3927-31}
}
Neuroprotective effects of a Group II metabotropic glutamate receptor agonist, LY379268, were examined in a neonatal rat model of hypoxia-ischemia (unilateral common carotid artery ligation followed by hypoxic exposure for 1.5h in 7-day-old rat pups). LY379268 administered 5 min after hypoxic exposure (2, 5, or 10 mg/kg, i.p.) significantly reduced brain… CONTINUE READING