Protection of mice with a divalent tuberculosis DNA vaccine encoding antigens Ag85B and MPT64.

@article{Tian2004ProtectionOM,
  title={Protection of mice with a divalent tuberculosis DNA vaccine encoding antigens Ag85B and MPT64.},
  author={Xia Tian and Hong Cai and Yu-xian Zhu},
  journal={Acta biochimica et biophysica Sinica},
  year={2004},
  volume={36 4},
  pages={269-76}
}
DNA vaccine may be a promising tool for controlling tuberculosis development. However, vaccines encoding single antigens of mycobacterium did not produce protective effect as BCG did. In the present study, we evaluated the immunogenicity and protective efficacy of a divalent DNA vaccine encoding two immunodominant antigens Ag85B and MPT64 of Mycobacterium tuberculosis. We found that both humoral and Th1-type (high IFN-gamma, low IL-4) cellular responses obtained from the divalent DNA vaccine… CONTINUE READING