Protection of mice from wild-type Sendai virus infection by a trypsin-resistant mutant, TR-2.

@article{Tashiro1985ProtectionOM,
  title={Protection of mice from wild-type Sendai virus infection by a trypsin-resistant mutant, TR-2.},
  author={Masato Tashiro and Morio Homma},
  journal={Journal of virology},
  year={1985},
  volume={53 1},
  pages={228-34}
}
A trypsin-resistant mutant of Sendai virus, TR-2, which could be activated by chymotrypsin but not by trypsin or the protease present in mouse lung, was inoculated intranasally into mice after being activated in vitro. TR-2 hardly brought about clinical illness or lung lesions in mice; the protease present in the lung could not activate the progeny virus… CONTINUE READING