Protection of mice from lethal influenza by defective interfering virus: T cell responses.

Abstract

The immune-mediated lethal influenza in C3H/He-mg (H-2k) mice infected with A/WSN influenza virus (H1N1) was investigated. A primary class I major histocompatibility complex-restricted, CD8+ cytotoxic T lymphocyte (CTL) response was found in the lungs with a peak activity at 5 days post-infection. Monoclonal antibody depletion in vivo showed that a lethal… (More)

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Cite this paper

@article{McLain1992ProtectionOM, title={Protection of mice from lethal influenza by defective interfering virus: T cell responses.}, author={Lesley McLain and Dr. Juliet Morgan and Nigel J. Dimmock}, journal={The Journal of general virology}, year={1992}, volume={73 ( Pt 2)}, pages={375-81} }