Protection of mice from inhaled ricin by vaccination with ricin or by passive treatment with heterologous antibody.

@article{Hewetson1993ProtectionOM,
  title={Protection of mice from inhaled ricin by vaccination with ricin or by passive treatment with heterologous antibody.},
  author={John F Hewetson and Victor R Rivera and Donald A. Creasia and P V Lemley and Meg Rippy and Mark A Poli},
  journal={Vaccine},
  year={1993},
  volume={11 7},
  pages={
          743-6
        }
}
Mice were vaccinated subcutaneously with 25 micrograms kg-1 of ricin in the presence of Freund's complete adjuvant or Ribi adjuvant, followed by a boost 14 days later with 50 micrograms kg-1 ricin in Freund's incomplete adjuvant or Ribi adjuvant, respectively. Three subsequent boosts at 28-day intervals with 25 micrograms kg-1 ricin yielded high anti-ricin antibody titres as determined by ELISA. Vaccinated animals were exposed to an aerosolized LD99 dose of ricin. With the exception of one… CONTINUE READING
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