Protection of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones.

@article{Yamaguchi1991ProtectionOM,
  title={Protection of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones.},
  author={Ken Yamaguchi and Naoaki Goto and Shigeru Kyuwa and Masanori Hayami and Yutaka Toyoda},
  journal={Journal of neuroimmunology},
  year={1991},
  volume={32 1},
  pages={1-9}
}
The protective effect of a mouse hepatitis virus type-4 (MHV-4)-specific CD8+ cytotoxic T cell clone and a CD4+ helper T cell clone was examined by the adoptive transfer into brains of mice lethally infected with MHV-4. Mice survived acute encephalitis if more than 5 x 10(5) cells of either type of the virus-specific T cell clones had been transferred into H-2-matched recipients by 1 day post-infection. Although the adoptive transfer of both types of the T cell clones suppressed viral growth… CONTINUE READING

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