Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA.

@article{Fikrig1991ProtectionOM,
  title={Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA.},
  author={Erol Fikrig and Stephen W. Barthold and Fred S. Kantor and Richard A Flavell},
  journal={The Journal of infectious diseases},
  year={1991},
  volume={164 6},
  pages={1224-7}
}
Mice immunized with recombinant outer surface protein A (OspA) in Freund's adjuvant or with intraperitoneal injections of live Escherichia coli expressing OspA have been shown to be protected from infection with Borrelia burgdorferi. To investigate the efficacy of oral vaccination, C3H/He mice were inoculated with 10(8) live E. coli expressing recombinant OspA by gavage and boosted in a similar manner on days 10, 20, 30, and 40. The animals developed serum IgG antibodies to OspA by immunoblot… CONTINUE READING

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