Protection of mice against Trypanosoma cruzi by immunization with paraflagellar rod proteins requires T cell, but not B cell, function.

@article{Miller1997ProtectionOM,
  title={Protection of mice against Trypanosoma cruzi by immunization with paraflagellar rod proteins requires T cell, but not B cell, function.},
  author={Mark J. Miller and Ruth A. Wrightsman and Gabrielle A. Stryker and Jerry E. Manning},
  journal={Journal of immunology},
  year={1997},
  volume={158 11},
  pages={5330-7}
}
Previous studies have shown that immunization of mice with the paraflagellar rod proteins (PAR) of Trypanosoma cruzi induces an immune response capable of protecting mice against an otherwise lethal challenge with this parasite. Herein, we define immunologic responses that do or do not play a critical role in PAR-mediated protection. Firstly, PAR-immunized… CONTINUE READING