Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope.

@article{Barnett2008ProtectionOM,
  title={Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope.},
  author={S Wienand Barnett and Indresh K. Srivastava and Elaine Kan and Fengmin Zhou and Amanda Goodsell and Anthony D. Cristillo and Maria Grazia Ferrai and Deborah E Weiss and Norman L. Letvin and David C. Montefiori and Ranajit Pal and Michael Vajdy},
  journal={AIDS},
  year={2008},
  volume={22 3},
  pages={339-48}
}
BACKGROUND Worldwide, the majority of human immunodeficiency virus (HIV) infections occur by heterosexual transmission. Thus, the development of a vaccine that can prevent intravaginal HIV infection is an important goal of AIDS vaccine research. OBJECTIVES To determine which single or combination of systemic and mucosal routes of immunizations of female rhesus macaques with an HIV-1 SF162 envelope protein vaccine induced protection against intravaginal challenge with SHIV. DESIGN Female… CONTINUE READING

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