Protection of low density lipoprotein oxidation by the antioxidant agent IRFI005, a new synthetic hydrophilic vitamin E analogue.

@article{Iuliano1999ProtectionOL,
  title={Protection of low density lipoprotein oxidation by the antioxidant agent IRFI005, a new synthetic hydrophilic vitamin E analogue.},
  author={Luigi Iuliano and Jens Zacho Pedersen and Christopher Camastra and Valentina Bello and Sara Ceccarelli and Francesco Violi},
  journal={Free radical biology & medicine},
  year={1999},
  volume={26 7-8},
  pages={858-68}
}
The oxidative modification of low density lipoprotein (LDL) is thought to be an important factor in the initiation and development of atherosclerosis. Antioxidants have been shown to protect LDL from oxidation and to inhibit atherosclerosis development in animals. Potent synthetic antioxidants are currently being tested, but they are not necessarily safe for human use. We here characterize the antioxidant activity of IRFI005, the active metabolite of Raxofelast (IRFI0016) that is a novel… CONTINUE READING
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