Protection of ischemic myocardium in diabetics by inhibition of electroneutral Na+-K+-2Cl- cotransporter.

@article{Ramasamy2001ProtectionOI,
  title={Protection of ischemic myocardium in diabetics by inhibition of electroneutral Na+-K+-2Cl- cotransporter.},
  author={Ravichandran Ramasamy and Jason Allen Payne and Jia Whang and Steven R. Bergmann and Saul Schaefer},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 2},
  pages={
          H515-22
        }
}
Diabetes increases both the incidence of cardiovascular disease and complications of myocardial infarction and heart failure. Studies using diabetic animals have shown that changes in myocardial sodium transporters result in alterations in intracellular sodium (Na(i)) homeostasis. Because the changes in sodium homeostasis can be due to increased entry of Na+ via the electroneutral Na+-K+-2Cl- cotransporter (NKCC), we conducted experiments in acute diabetic hearts to determine if 1) net inward… CONTINUE READING

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