Protection of insulin-producing cells against toxicity of dexamethasone by catalase overexpression.

@article{Roma2009ProtectionOI,
  title={Protection of insulin-producing cells against toxicity of dexamethasone by catalase overexpression.},
  author={Let{\'i}cia Prates Roma and Jos{\'e} Roberto Bosqueiro and Daniel Andrade Cunha and Everardo Magalh{\~a}es Carneiro and Ewa Gurgul-Convey and Sigurd Lenzen and Ant{\^o}nio Carlos Boschero and Kleber L.A. Souza},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 10},
  pages={1386-93}
}
Pancreatic beta cells are very sensitive to reactive oxygen species (ROS) and this might play an important role in beta cell death in diabetes. Dexamethasone is a synthetic diabetogenic glucocorticoid, which impairs pancreatic beta cell function. Therefore we investigated the toxicity of dexamethasone in RINm5F insulin-producing cells and its dependence on the expression level of the antioxidant enzyme catalase, which inactivates hydrogen peroxide. This was correlated with oxidative stress and… CONTINUE READING
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