Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation.

@article{Baharom2015ProtectionOH,
  title={Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation.},
  author={Faezzah Baharom and Saskia Thomas and Andrea Bieder and Maria Hellm{\'e}r and Julia Volz and Kerrie J. Sandgren and Gerald M McInerney and Gunilla B. Karlsson Hedestam and Ira Mellman and Anna Smed-S{\"o}rensen},
  journal={Journal of immunology},
  year={2015},
  volume={194 9},
  pages={4422-30}
}
The proinflammatory microenvironment in the respiratory airway induces maturation of both resident and infiltrating dendritic cells (DCs) upon influenza A virus (IAV) infection. This results in upregulation of antiviral pathways as well as modulation of endocytic processes, which affect the susceptibility of DCs to IAV infection. Therefore, it is highly relevant to understand how IAV interacts with and infects mature DCs. To investigate how different subsets of human myeloid DCs (MDCs) involved… CONTINUE READING
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