Protection of human corneal epithelial cells from hypoxia-induced disruption of barrier function by hepatocyte growth factor.

@article{Kimura2010ProtectionOH,
  title={Protection of human corneal epithelial cells from hypoxia-induced disruption of barrier function by hepatocyte growth factor.},
  author={Kazuhiro Kimura and Shinichiro Teranishi and Koji Kawamoto and Teruo Nishida},
  journal={Experimental eye research},
  year={2010},
  volume={90 2},
  pages={337-43}
}
The barrier function of the corneal epithelium maintains corneal homeostasis and is mediated by tight junctions (TJs) and adherens junctions (AJs). It is also susceptible to disruption by hypoxia. We have now examined the effects of hypoxia on TJs and AJs as well as on barrier function in human corneal epithelial (HCE) cells. Moreover, we investigated whether such effects of hypoxia might be modulated by hepatocyte growth factor (HGF). The subcellular distribution of the TJ proteins ZO-1 and… CONTINUE READING