Protection of human colon epithelial cells against deoxycholate by rottlerin

@article{Longpre2008ProtectionOH,
  title={Protection of human colon epithelial cells against deoxycholate by rottlerin},
  author={Jennifer M. Longpre and G. Y. Loo},
  journal={Apoptosis},
  year={2008},
  volume={13},
  pages={1162-1171}
}
The bile salt, deoxycholate (DOC), can harm cells and cause disease. Hence, there is interest in identifying compounds capable of protecting cells against DOC. In HCT-116 colon epithelial cells, DOC increased generation of reactive oxygen species and caused DNA damage and apoptosis. These effects of DOC were inhibited by rottlerin, which is a phenolic compound of plant origin. In elucidating its mechansim, rottlerin prevented the release of cytochrome c from mitochondria into cytosol, and also… CONTINUE READING
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