Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta.

@article{Fang2009ProtectionOE,
  title={Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta.},
  author={Xiang-qian Fang and Mei Fang and Shunwu Fan and Chuan-long Gu},
  journal={Chinese medical journal},
  year={2009},
  volume={122 14},
  pages={1631-5}
}
BACKGROUND Erythropoietin (EPO) functions as a tissue-protective cytokine in addition to its crucial hormonal role in red cell production and neuron protection. This study aimed to determine the neuron protective effect of erythropoietin on experimental rats enduring spinal cord injury (SCI) by assessing thrombospondin-1 (TSP-1) level and transforming growth factor-beta (TGF-beta) in the development of a rat model of SCI. METHODS Sixty Sprague-Dawley rats were randomly assigned to three… CONTINUE READING
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