Protection of energy status of hypoxic cardiomyocytes by mild acidosis.

@article{Koop1992ProtectionOE,
  title={Protection of energy status of hypoxic cardiomyocytes by mild acidosis.},
  author={A Koop and Hans Michael Piper},
  journal={Journal of molecular and cellular cardiology},
  year={1992},
  volume={24 1},
  pages={
          55-65
        }
}
The question was investigated whether mild acidosis can provide energetic protection on the hypoxic myocardial cell by mechanisms other than negative inotropy. The experimental model used was quiescent ventricular cardiomyocytes isolated from the adult rat. The extracellular pH (pHe) in modified hypoxic Tyrode's solution was varied by changing the concentration of bicarbonate at constant PCO2. The intracellular pH (pHi) was determined with 2',7'-bis-(carboxyethyl)5-(6')-carboxyfluorescein. When… CONTINUE READING

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