Protection of cultured Chinese hamster ovary cells by the aminothiol WR-255591 from the lethal and DNA-damaging effects of fast neutrons.

@article{Vanankeren1989ProtectionOC,
  title={Protection of cultured Chinese hamster ovary cells by the aminothiol WR-255591 from the lethal and DNA-damaging effects of fast neutrons.},
  author={S. C. Vanankeren and L. Milas and D. Murray},
  journal={International journal of radiation oncology, biology, physics},
  year={1989},
  volume={16 5},
  pages={
          1205-8
        }
}
We examined the radioprotective effect of the aminothiol WR-255591 on cultured aerated Chinese hamster ovary cells irradiated with cyclotron-generated fast neutrons. The effects of a 30 min pretreatment with 6 mM WR-255591 on the induction of DNA single-strand breaks (SSBs) and double-strand breaks (DSBs) were measured using alkaline (pH 12.1) and neutral (pH 7.0) filter elution, respectively. Molecular protection factors (PFs) calculated from these data were compared with the PF measured using… Expand
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