Protection of cortical neurons against oxygen-glucose deprivation and N-methyl-D-aspartate by DIDS and SITS.

@article{Tauskela2003ProtectionOC,
  title={Protection of cortical neurons against oxygen-glucose deprivation and N-methyl-D-aspartate by DIDS and SITS.},
  author={Joseph S. Tauskela and Geoff A. Mealing and Tanya Comas and E. Brunette and Robert Monette and Daniel L. Small and P. D. Morley},
  journal={European journal of pharmacology},
  year={2003},
  volume={464 1},
  pages={17-25}
}
The Cl(-) channel blockers, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) or 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS) dose-dependently protected against oxygen-glucose deprivation in cultured rat cortical neurons. DIDS or SITS attenuated oxygen-glucose deprivation-induced increases in extracellular glutamate concentrations and intracellular Ca(2+). DIDS or SITS provided moderate protection against N-methyl-D-aspartate (NMDA) toxicity and decreased NMDA… CONTINUE READING