Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160

@article{Berman1990ProtectionOC,
  title={Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160},
  author={Phillip W Berman and Timothy J. Gregory and Lavon Riddle and Gerald Nakamura and Mark A. Champe and James P. Porter and F Wurm and Robert D. Hershberg and Elaine K Cobb and Jorg W. Eichberg},
  journal={Nature},
  year={1990},
  volume={345},
  pages={622-625}
}
THE development of a vaccine to provide protective immunity to human immunodeficiency virus type 1 (HIV-1), the virus causing AIDS, would be the most practical method to control its spread. Subunit vaccines consisting of virus envelope glycoproteins, produced by recombinant DNA technology, are effective in preventing viral infections1. We have now used this approach in the development of a candidate AIDS vaccine. Chimpanzees were immunized with recombinant forms of the HIV-1 glycoproteins gp120… 

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The immune response elicited against the rgp120 was not effective in preventing viral infection after intravenous challenge with HIV-1 and the implications of these results on HIV- 1 vaccine development are discussed.

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