Protection of cartilage in chemical synovectomy by perfusion.


The authors examined the effect of osmium tetroxide (OsO4) on the synovial membrane and cartilage of the rat knee joints by light-, polarization-, and electron microscope. They found that the synovial membrane undergoes severe damage after a 10 min exposure to OsO4. Removing the OsO4 from the joint cavity by perfusion after the 10 min exposure, there was no… (More)


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