Protection of TRPC7 cation channels from calcium inhibition by closely associated SERCA pumps.

@article{Lemonnier2006ProtectionOT,
  title={Protection of TRPC7 cation channels from calcium inhibition by closely associated SERCA pumps.},
  author={Lo{\"i}c Lemonnier and Mohamed Trebak and Jean-Philippe Li{\`e}vremont and Gary St J Bird and James W Putney},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 3},
  pages={
          503-5
        }
}
Numerous studies have demonstrated that members of the transient receptor potential (TRP) superfamily of channels are involved in regulated Ca2+ entry. Additionally, most Ca2+-permeable channels are themselves regulated by Ca2+, often in complex ways. In the current study, we have investigated the regulation of TRPC7, a channel known to be potentially activated by both store-operated mechanisms and non-store-operated mechanisms involving diacylglycerols. Surprisingly, we found that activation… CONTINUE READING

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TRPC channels function independently of STIM1 and Orai1.

  • The Journal of physiology
  • 2009
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