Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination.

@article{Cirillo2009ProtectionOM,
  title={Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination.},
  author={Suat L. G. Cirillo and Selvakumar Subbian and Bing Chen and Torin R. Weisbrod and William Robert Jacobs and Jeffrey David Cirillo},
  journal={Infection and immunity},
  year={2009},
  volume={77 6},
  pages={2557-67}
}
Persistence of Mycobacterium tuberculosis in humans represents a major roadblock to elimination of tuberculosis. We describe identification of a locus in M. tuberculosis, mel2, that displays similarity to bacterial bioluminescent loci and plays an important role during persistence in mice. We constructed a deletion of the mel2 locus and found that the mutant displays increased susceptibility to reactive oxygen species (ROS). Upon infection of mice by aerosol the mutant grows normally until the… CONTINUE READING

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