Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies.

@article{Mascola1999ProtectionOM,
  title={Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies.},
  author={John R. Mascola and Mark G. Lewis and Gabriela M Stiegler and Dylan Harris and Thomas C Vancott and Deborah A. Hayes and Mark K. Louder and Charles R Brown and Christine V Sapan and Sarah Schlesinger Frankel and Yonggan Lu and Merlin L. Robb and Hermann Katinger and Deborah L. Birx},
  journal={Journal of virology},
  year={1999},
  volume={73 5},
  pages={4009-18}
}
The role of antibody in protection against human immunodeficiency virus (HIV-1) has been difficult to study in animal models because most primary HIV-1 strains do not infect nonhuman primates. Using a chimeric simian/human immunodeficiency virus (SHIV) based on the envelope of a primary isolate (HIV-89.6), we performed passive-transfer experiments in rhesus macaques to study the role of anti-envelope antibodies in protection. Based on prior in vitro data showing neutralization synergy by… CONTINUE READING

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