Protection of DNA during early development: adaptations and evolutionary consequences.

@article{Epel2003ProtectionOD,
  title={Protection of DNA during early development: adaptations and evolutionary consequences.},
  author={David Epel},
  journal={Evolution & development},
  year={2003},
  volume={5 1},
  pages={83-8}
}
  • David Epel
  • Published 2003 in Evolution & development
The rapidly dividing cleavage stages of embryos do not have the typical responses to cell damage, such as induction of the heat shock response, use of mitotic checkpoints, or use of apoptosis to eliminate severely damaged cells. This could create problems with integrity of DNA, but the solution in these embryos appears to be a "be prepared" approach, in which specific adaptations are used to minimize DNA damage during cleavage and the use of apoptosis at the mid-blastula transition to remove… CONTINUE READING

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