Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen.

@article{Jones2001ProtectionOA,
  title={Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen.},
  author={Trevor R. Jones and David L. Narum and Alfonso S Gozalo and Jo{\~a}o Aguiar and Steven R. Fuhrmann and H-F. Liang and J. David Haynes and J. Kathleen Moch and Carmen L{\'a}zaro de Lucas and Trong Tuan Luu and Alan J. Magill and Stephen L. Hoffman and Betty Kim Lee Sim},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={183 2},
  pages={
          303-312
        }
}
Aotus monkeys received 4 doses of Plasmodium falciparum EBA-175 region II vaccine as plasmid DNA (Dv-Dv) or recombinant protein in adjuvant (Pv-Pv) or as 3 doses of DNA and 1 dose of protein (Dv-Pv). After 3 doses, antibody titers were approximately 10(4) in DNA-immunized monkeys and 10(6) in protein-immunized monkeys. A fourth dose did not significantly boost antibody responses in the Dv-Dv only or Pv-Pv only groups, but titers were boosted to approximately 10(6) in monkeys in the Dv-Pv group… CONTINUE READING
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