• Corpus ID: 101360573

Protection of Amino Group in the 2-Aminomethylphenylacetic Acid,the Intermediate of Ceforanide

@article{Ronggeng2008ProtectionOA,
  title={Protection of Amino Group in the 2-Aminomethylphenylacetic Acid,the Intermediate of Ceforanide},
  author={Wang Rong-geng},
  journal={Fine and Specialty Chemicals},
  year={2008}
}
The amino-group of 2-aminomethylphenylacetic acid was protected by tert- butyloxycabonyl(BOC)group,the protection was conducted via condensation in the mixed solvent composed of dioxane,dichloromethane and water in the presence of NaOH or triethylamine.The optimal reaction conditions were determined and the optimum yield could be reached up to 88.1%.The structure of target product was confirmed by IR,HPLC and NMR. 
The comparison of protecting methods to the amino group in 2-Aminomethylphenylacetic acid
Abstract2-Aminomethylphenylacetic acid is an important intermediate of ceforanide, and this article compared two different protecting agents for protecting the amino group in