Protection of ATP-depleted cells by impermeant strychnine derivatives: implications for glycine cytoprotection.

Abstract

Glycine and structurally related amino acids with activities at chloride channel receptors in the central nervous system also have robust protective effects against cell injury by ATP depletion. The glycine receptor antagonist strychnine shares this protective activity. An essential step toward identification of the molecular targets for these compounds is… (More)

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