Protection of 2'-hydroxy functions of ribonucleosides.

  • Crystal Reese
  • Published 2001 in Current protocols in nucleic acid chemistry

Abstract

The main purpose of this article is to discuss 2'-protection in the context of effective oligoribonucleotide synthesis. Emphasis is placed on the 2'-protecting groups of choice in the synthesis of oligo-and polyribonucleotides, and the requirements that a protective group must satisfy to become the 2'-hydroxyl-protecting group of choice. Finally, the unit… (More)
DOI: 10.1002/0471142700.nc0202s00

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