Protection from postsplenectomy sepsis: Effect of prophylactic penicillin and pneumococcal vaccine on clearance of type 3 Pneumococcus.

Abstract

The intravascular clearance of type 3 Streptococcus pneumoniae was studied in Sprague-Dawley rats. One hundred animals were divided into the following five equal groups: I--splenic mobilization, II--splenectomy, III--splenectomy plus pneumococcal vaccine, IV--splenectomy plus 50,000 U of penicillin prophylaxis, V--splenectomy plus 300,000 U of penicillin… (More)

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