Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine.

@article{Kitces1977ProtectionFO,
  title={Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine.},
  author={E N Kitces and Page S. Morahan and J. Grant Tew and Byron K Murray},
  journal={Infection and immunity},
  year={1977},
  volume={16 3},
  pages={955-60}
}
The effect of immunization with inactivated herpes virus vaccines, including a vaccine free of all nucleic acid, was investigated in a mouse model system. Protection against oral lesions induced by herpes simplex virus type 1 was demonstrated by several criteria: (i) reduction in the incidence and severity of primary oral lesions; (ii) decrease in acute and latent infection of the regional sensory ganglia; and (iii) protection from viral encephalitis and death. The immune response of mice to… CONTINUE READING