Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.

@article{Yadav2011ProtectionFO,
  title={Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.},
  author={Hariom Yadav and Celia Quijano and Anil Kumar Kamaraju and Oksana Gavrilova and Rana Malek and Weiping Chen and Patricia M. Zerfas and Duan Zhigang and Elizabeth C Wright and Christina H. Stuelten and Peter Sun and Scott Lonning and Monica K. Skarulis and Anne E. Sumner and Toren Finkel and Sushil G. Rane},
  journal={Cell metabolism},
  year={2011},
  volume={14 1},
  pages={67-79}
}
Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the TGF-β/Smad3 signaling pathway in regulating glucose and energy homeostasis. Smad3-deficient mice are protected from diet-induced obesity and diabetes. Interestingly, the metabolic protection is accompanied by Smad3(-)(/-) white adipose tissue acquiring the bioenergetic and gene expression profile of brown fat/skeletal muscle. Smad3… CONTINUE READING
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