Protection from nitrosative stress: a central role for microbial flavohemoglobin.

@article{Forrester2012ProtectionFN,
  title={Protection from nitrosative stress: a central role for microbial flavohemoglobin.},
  author={Michael T. Forrester and Matthew W Foster},
  journal={Free radical biology & medicine},
  year={2012},
  volume={52 9},
  pages={
          1620-33
        }
}
Nitric oxide (NO) is an inevitable product of life in an oxygen- and nitrogen-rich environment. This reactive diatomic molecule exhibits microbial cytotoxicity, in large part by facilitating nitrosative stress and inhibiting heme-containing proteins within the aerobic respiratory chain. Metabolism of NO is therefore essential for microbial life. In many bacteria, fungi, and protozoa, the evolutionarily ancient flavohemoglobin (flavoHb) converts NO and O(2) to inert nitrate (NO(3)(-)) and… CONTINUE READING
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