Protection from nitrosative stress: a central role for microbial flavohemoglobin.

  title={Protection from nitrosative stress: a central role for microbial flavohemoglobin.},
  author={Michael T. Forrester and Matthew W Foster},
  journal={Free radical biology & medicine},
  volume={52 9},
Nitric oxide (NO) is an inevitable product of life in an oxygen- and nitrogen-rich environment. This reactive diatomic molecule exhibits microbial cytotoxicity, in large part by facilitating nitrosative stress and inhibiting heme-containing proteins within the aerobic respiratory chain. Metabolism of NO is therefore essential for microbial life. In many bacteria, fungi, and protozoa, the evolutionarily ancient flavohemoglobin (flavoHb) converts NO and O(2) to inert nitrate (NO(3)(-)) and… CONTINUE READING
Highly Cited
This paper has 47 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 32 extracted citations

Is the flavohemoglobin a nitric oxide dioxygenase?

Free radical biology & medicine • 2012
View 6 Excerpts
Highly Influenced

Structure and function of haemoglobins.

Blood cells, molecules & diseases • 2018
View 1 Excerpt