Protection from lymphoma cell metastasis in ICAM-1 mutant mice: a posthoming event.

@article{Aoudjit1998ProtectionFL,
  title={Protection from lymphoma cell metastasis in ICAM-1 mutant mice: a posthoming event.},
  author={Fawzi Aoudjit and Edouard F. Potworowski and Timothy A Springer and Yves St-Pierre},
  journal={Journal of immunology},
  year={1998},
  volume={161 5},
  pages={2333-8}
}
It has been hypothesized that the intercellular adhesion receptors used by normal cells could also be operative in the spreading of circulating malignant cells to target organs. In the present work, we show that genetic ablation of the ICAM-1 gene confers resistance to T cell lymphoma metastasis. Following i.v. inoculation of LFA-1-expressing malignant T lymphoma cells, we found that ICAM-1-deficient mice were almost completely resistant to the development of lymphoid malignancy compared with… CONTINUE READING
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