Protection from lethal herpes simplex virus type 1 infection by vaccination with a UL41-deficient recombinant strain.


UNLABELLED The UL41 gene of herpes simplex virus type 1 (HSV-1) encodes a virion host shut off protein which is involved in immune evasion. The growth and virulence of HSV-1 is markedly reduced by the deletion of UL41. In this report, the UL41-deleted recombinant HSV-1 strain VR∆41 was evaluated as a prophylactic live attenuated vaccine against lethal HSV-1… (More)
DOI: 10.5387/fms.2015-24


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