Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.

@article{Roger2009ProtectionFL,
  title={Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.},
  author={Thierry W. Roger and C{\'e}line Froidevaux and Didier le Roy and Marlies Knaup Reymond and Anne-Laure Chanson and Davide Mauri and Kim M Burns and B{\'e}at Michel Riederer and Shizuo Akira and Thierry Calandra},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 7},
  pages={2348-52}
}
Toll-like receptor 4 (TLR4), the signal-transducing molecule of the LPS receptor complex, plays a fundamental role in the sensing of LPS from gram-negative bacteria. Activation of TLR4 signaling pathways by LPS is a critical upstream event in the pathogenesis of gram-negative sepsis, making TLR4 an attractive target for novel antisepsis therapy. To validate… CONTINUE READING