Protection from guanethidine-induced neuronal destruction by nerve growth factor: Effect of NGF on immune function

@article{Manning1985ProtectionFG,
  title={Protection from guanethidine-induced neuronal destruction by nerve growth factor: Effect of NGF on immune function},
  author={Pamela T. Manning and John H. Russell and Barbara Simmons and Eugene Malcolm Johnson},
  journal={Brain Research},
  year={1985},
  volume={340},
  pages={61-69}
}
The chronic administration of guanethidine causes an immune-mediated destruction of sympathetic neurons in rats. Destruction can be prevented by various immunosuppressive agents, including gamma-irradiation and cyclophosphamide, as well as by administration with nerve growth factor (NGF). Experiments were conducted to determine whether: (1) NGF prevented accumulation of guanethidine within sympathetic neurons; and (2) NGF caused an inhibition of immune function by either blocking proliferation… CONTINUE READING

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