Protection from diabetes-induced peripheral sensory neuropathy--a role for elevated glyoxalase I?

@article{Jack2012ProtectionFD,
  title={Protection from diabetes-induced peripheral sensory neuropathy--a role for elevated glyoxalase I?},
  author={Megan Marie Jack and Janelle M. Ryals and Douglas E Wright},
  journal={Experimental neurology},
  year={2012},
  volume={234 1},
  pages={62-9}
}
Diabetic neuropathy is a common complication of diabetes mellitus with over half of all patients developing neuropathy symptoms due to sensory nerve damage. Diabetes-induced hyperglycemia leads to the accelerated production of advanced glycation end products (AGEs) that alter proteins, thereby leading to neuronal dysfunction. The glyoxalase enzyme system, specifically glyoxalase I (GLO1), is responsible for detoxifying precursors of AGEs, such as methylglyoxal and other reactive dicarbonyls… CONTINUE READING
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