Protection from cerebral ischemia by U-50,488E, a specific kappa opioid analgesic agent.

Abstract

U-50,488E is a novel analgesic agent with a specific agonist property on the kappa opioid receptor. It is found to protect against the lethal effect of temporary bilateral carotid occlusion (BCO) in Mongolian gerbils and rats of the Fischer strain. Pretreatment with U-50,488E in gerbils before 7 min of BCO reduced the development of behavioral hyperactivity… (More)

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Cite this paper

@article{Tang1985ProtectionFC, title={Protection from cerebral ischemia by U-50,488E, a specific kappa opioid analgesic agent.}, author={Andrew H. Tang}, journal={Life sciences}, year={1985}, volume={37 16}, pages={1475-82} }