Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH.

@article{Braun2007ProtectionFB,
  title={Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH.},
  author={Johann Sebastian Braun and Konstantin Prass and Ulrich Dirnagl and Andreas Meisel and Christian Meisel},
  journal={Experimental neurology},
  year={2007},
  volume={206 2},
  pages={183-91}
}
Infarction size and infections are important determinants of stroke outcome in humans. Bacterial infections are promoted by stroke-induced immunodeficiency which in experimental stroke is mainly characterized by extensive lymphocyte apoptosis and dysfunction. Pharmacological inhibition of caspases may improve stroke outcome not only by reducing apoptotic brain damage but also by attenuating stroke-induced immunodeficiency. We investigated the effects of systemic administration of the novel, non… CONTINUE READING
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