Protection from bacterial infection by a single vaccination with replication-deficient mutant herpes simplex virus type 1.

@article{Lauterbach2004ProtectionFB,
  title={Protection from bacterial infection by a single vaccination with replication-deficient mutant herpes simplex virus type 1.},
  author={Henning Lauterbach and Kristen M. Kerksiek and Dirk H Busch and Elena Berto and Aleksandra Bozac and Penelope Mavromara and Roberto Manservigi and Alberto Luis Epstein and Peggy Marconi and Thomas Brocker},
  journal={Journal of virology},
  year={2004},
  volume={78 8},
  pages={4020-8}
}
Adaptive immune responses in which CD8(+) T cells recognize pathogen-derived peptides in the context of major histocompatibility complex class I molecules play a major role in the host defense against infection with intracellular pathogens. Cells infected with intracellular bacteria such as Listeria monocytogenes, Salmonella enterica serovar Typhimurium, or Mycobacterium tuberculosis are directly lysed by cytotoxic CD8(+) T cells. For this reason, current vaccines for intracellular pathogens… CONTINUE READING
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