Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis.

@article{Rulli2011ProtectionFA,
  title={Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis.},
  author={Nestor E. Rulli and Michael S. Rolph and Anon Srikiatkhachorn and Surapee Anantapreecha and Angelo Guglielmotti and Suresh Mahalingam},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={204 7},
  pages={1026-30}
}
Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment… CONTINUE READING

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