Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine.

@article{Komiyama2005ProtectionFA,
  title={Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine.},
  author={Tomoko Komiyama and Joel A Swanson and Robert S Fuller},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 9},
  pages={3875-82}
}
Cell surface proteolytic processing of anthrax protective antigen by furin or other furin-related proteases is required for its oligomerization, endocytosis, and function as a translocon for anthrax lethal and edema factors. Countering toxin lethality is essential to developing effective chemotherapies for anthrax infections that have proceeded beyond the stage at which antibiotics are effective. The primary target for toxin is the macrophage, which can be killed by lethal factor via both… CONTINUE READING

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